Mast cells line the bronchial mucous membranes and are the primary instigator for asthma symptoms. When they release chemicals, inflammation and airway obstruction can occur. These conditions lead to lowering thresholds to stimuli, so the airways become even more sensitive and hyper-responsive. Recurrent bouts of inflammation can ultimately lead to scarring and permanent narrowing of the airways. This permanent narrowing is called airway remodeling.
